The reuse of metal powders in directed energy deposition using laser powder offers promising sustainability benefits for additive manufacturing, yet its impact on part quality remains unknown. This study investigates the influence of powder reuse on the directed energy deposition process of Inconel 625. Virgin powder was first characterized in terms of flowability, morphology, size and chemical composition, then used to manufacture parts under fixed process parameters. These parts were analysed through two configurations (as-built and hot isostatically pressed) to assess microstructural evolution and mechanical performance. Results show that hot isostatic pressing reduces porosity and promotes grain recrystallization, enhancing ductility while decreasing tensile strength. Recovered powders from one manufacturing cycle, were also characterized. Particle size distribution and morphology remained stable, interstitial contents, particularly oxygen, increased, potentially affecting laser-material interaction and melt pool behaviour in future production. These findings highlight the importance of evaluating powder reuse through a full-process approach, from powder to final part. Future work will focus on the tensile and fatigue performance of parts produced with recovered powders.